Somatostatin receptor in breast cancer and axillary nodes: study with scintigraphy, histopathology and receptor autoradiography.
Identifieur interne : 003916 ( Main/Exploration ); précédent : 003915; suivant : 003917Somatostatin receptor in breast cancer and axillary nodes: study with scintigraphy, histopathology and receptor autoradiography.
Auteurs : RBID : pubmed:10930087English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Autoradiography, Axilla, Breast Neoplasms (metabolism), Breast Neoplasms (radionuclide imaging), Carcinoma, Ductal, Breast (metabolism), Carcinoma, Ductal, Breast (radionuclide imaging), Carcinoma, Lobular (metabolism), Carcinoma, Lobular (radionuclide imaging), Female, Humans, Indium Radioisotopes (diagnostic use), Lymph Nodes (metabolism), Lymph Nodes (radionuclide imaging), Lymphatic Metastasis, Middle Aged, Predictive Value of Tests, Prospective Studies, Receptors, Somatostatin (analysis), Receptors, Somatostatin (metabolism), Sensitivity and Specificity, Somatostatin (analogs & derivatives), Somatostatin (diagnostic use).
- MESH :
- chemical , analogs & derivatives : Somatostatin.
- chemical , analysis : Receptors, Somatostatin.
- chemical , diagnostic use : Indium Radioisotopes, Somatostatin.
- metabolism : Breast Neoplasms, Carcinoma, Ductal, Breast, Carcinoma, Lobular, Lymph Nodes, Receptors, Somatostatin.
- radionuclide imaging : Breast Neoplasms, Carcinoma, Ductal, Breast, Carcinoma, Lobular, Lymph Nodes.
- Adult, Aged, Aged, 80 and over, Autoradiography, Axilla, Female, Humans, Lymphatic Metastasis, Middle Aged, Predictive Value of Tests, Prospective Studies, Sensitivity and Specificity.
Abstract
We conducted a prospective analysis of somatostatin receptor scintigraphy using (111)In radiolabeled pentetreotide, a somatostatin analog, in patients with breast cancer in the aim to visualize the primary tumor and axillary or parasternal metastatic extension because some malignant breast tumors express somatostatin receptors (SS-R) in 50%, approximately. An analysis of SS-R was performed by autoradiography.
PubMed: 10930087
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Somatostatin receptor in breast cancer and axillary nodes: study with scintigraphy, histopathology and receptor autoradiography.</title><author><name sortKey="Alberini, J L" uniqKey="Alberini J">J L Albérini</name><affiliation wicri:level="1"><nlm:affiliation>Nuclear Medicine Department, Centre de Recherche et de Lutte Contre le Cancer, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Nuclear Medicine Department, Centre de Recherche et de Lutte Contre le Cancer, Rennes</wicri:regionArea><placeName><region type="région">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Meunier, B" uniqKey="Meunier B">B Meunier</name></author><author><name sortKey="Denzler, B" uniqKey="Denzler B">B Denzler</name></author><author><name sortKey="Devillers, A" uniqKey="Devillers A">A Devillers</name></author><author><name sortKey="Tass, P" uniqKey="Tass P">P Tass</name></author><author><name sortKey="Dazord, L" uniqKey="Dazord L">L Dazord</name></author><author><name sortKey="Le Simple, T" uniqKey="Le Simple T">T Le Simple</name></author><author><name sortKey="Laissue, J" uniqKey="Laissue J">J Laissue</name></author><author><name sortKey="De Jong, R" uniqKey="De Jong R">R de Jong</name></author><author><name sortKey="Le Cloirec, J" uniqKey="Le Cloirec J">J Le Cloirec</name></author><author><name sortKey="Reubi, J C" uniqKey="Reubi J">J C Reubi</name></author><author><name sortKey="Bourguet, P" uniqKey="Bourguet P">P Bourguet</name></author></titleStmt><publicationStmt><date when="2000">2000</date><idno type="RBID">pubmed:10930087</idno><idno type="pmid">10930087</idno><idno type="wicri:Area/Main/Corpus">003C28</idno><idno type="wicri:Area/Main/Curation">003C28</idno><idno type="wicri:Area/Main/Exploration">003916</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Autoradiography</term><term>Axilla</term><term>Breast Neoplasms (metabolism)</term><term>Breast Neoplasms (radionuclide imaging)</term><term>Carcinoma, Ductal, Breast (metabolism)</term><term>Carcinoma, Ductal, Breast (radionuclide imaging)</term><term>Carcinoma, Lobular (metabolism)</term><term>Carcinoma, Lobular (radionuclide imaging)</term><term>Female</term><term>Humans</term><term>Indium Radioisotopes (diagnostic use)</term><term>Lymph Nodes (metabolism)</term><term>Lymph Nodes (radionuclide imaging)</term><term>Lymphatic Metastasis</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Prospective Studies</term><term>Receptors, Somatostatin (analysis)</term><term>Receptors, Somatostatin (metabolism)</term><term>Sensitivity and Specificity</term><term>Somatostatin (analogs & derivatives)</term><term>Somatostatin (diagnostic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Somatostatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Receptors, Somatostatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Indium Radioisotopes</term><term>Somatostatin</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Breast Neoplasms</term><term>Carcinoma, Ductal, Breast</term><term>Carcinoma, Lobular</term><term>Lymph Nodes</term><term>Receptors, Somatostatin</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Breast Neoplasms</term><term>Carcinoma, Ductal, Breast</term><term>Carcinoma, Lobular</term><term>Lymph Nodes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Autoradiography</term><term>Axilla</term><term>Female</term><term>Humans</term><term>Lymphatic Metastasis</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Prospective Studies</term><term>Sensitivity and Specificity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We conducted a prospective analysis of somatostatin receptor scintigraphy using (111)In radiolabeled pentetreotide, a somatostatin analog, in patients with breast cancer in the aim to visualize the primary tumor and axillary or parasternal metastatic extension because some malignant breast tumors express somatostatin receptors (SS-R) in 50%, approximately. An analysis of SS-R was performed by autoradiography.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">10930087</PMID><DateCreated><Year>2000</Year><Month>11</Month><Day>15</Day></DateCreated><DateCompleted><Year>2001</Year><Month>01</Month><Day>18</Day></DateCompleted><DateRevised><Year>2004</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0167-6806</ISSN><JournalIssue CitedMedium="Print"><Volume>61</Volume><Issue>1</Issue><PubDate><Year>2000</Year><Month>May</Month></PubDate></JournalIssue><Title>Breast cancer research and treatment</Title><ISOAbbreviation>Breast Cancer Res. Treat.</ISOAbbreviation></Journal><ArticleTitle>Somatostatin receptor in breast cancer and axillary nodes: study with scintigraphy, histopathology and receptor autoradiography.</ArticleTitle><Pagination><MedlinePgn>21-32</MedlinePgn></Pagination><Abstract><AbstractText Label="UNLABELLED">We conducted a prospective analysis of somatostatin receptor scintigraphy using (111)In radiolabeled pentetreotide, a somatostatin analog, in patients with breast cancer in the aim to visualize the primary tumor and axillary or parasternal metastatic extension because some malignant breast tumors express somatostatin receptors (SS-R) in 50%, approximately. An analysis of SS-R was performed by autoradiography.</AbstractText><AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">Thirteen patients with clinically suspected breast tumors (T1, T2), and at least one palpable axillary node (N1) were included. In vivo planar scintigrams were acquired 1, 4, and 24 h after subcutaneous, then after intravenous injections (24 h delay between injections). Improved (111)In-pentetreotide uptake in invaded nodes after subcutaneous injection was hypothesized. Ex vivo scintigrams of surgical specimens were also acquired immediately after tumor resection and axillary dissection. Pathological examination and receptor autoradiography were performed on all surgical specimens.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Among 11 pathologically proven malignant tumors (9 ductal and 2 lobular carcinomas), only four were scintigraphically visible although six expressed SS-R receptors in vitro. Among six pathologically proven malignant nodes, four expressed SS-R, including two visualized scintigraphically. Scintigrams acquired after subcutaneous injections were less sensitive than after intravenous injections. There were no false positive. False negatives occurred in cases with small tumors with low-density or heterogeneously distributed SS-R. There was no significant difference by histological type or prognostic factors.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Somatostatin receptor scintigraphy does not appear to be sensitive enough to evaluate axillary node extension of breast cancer or even to confirm the presence of tumoral tissue, and this whatever the administration route for (111)In-pentetreotide.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Albérini</LastName><ForeName>J L</ForeName><Initials>JL</Initials><Affiliation>Nuclear Medicine Department, Centre de Recherche et de Lutte Contre le Cancer, Rennes, France.</Affiliation></Author><Author ValidYN="Y"><LastName>Meunier</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Denzler</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Devillers</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Tass</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Dazord</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Le Simple</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Laissue</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>de Jong</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Le Cloirec</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Reubi</LastName><ForeName>J C</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>Bourguet</LastName><ForeName>P</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>NETHERLANDS</Country><MedlineTA>Breast Cancer Res Treat</MedlineTA><NlmUniqueID>8111104</NlmUniqueID><ISSNLinking>0167-6806</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Receptors, Somatostatin</NameOfSubstance></Chemical><Chemical><RegistryNumber>138661-02-6</RegistryNumber><NameOfSubstance>pentetreotide</NameOfSubstance></Chemical><Chemical><RegistryNumber>51110-01-1</RegistryNumber><NameOfSubstance>Somatostatin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Autoradiography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Axilla</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName MajorTopicYN="N">metabolism</QualifierName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Carcinoma, Ductal, Breast</DescriptorName><QualifierName MajorTopicYN="N">metabolism</QualifierName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Carcinoma, Lobular</DescriptorName><QualifierName MajorTopicYN="N">metabolism</QualifierName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Lymph Nodes</DescriptorName><QualifierName MajorTopicYN="N">metabolism</QualifierName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Lymphatic Metastasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Receptors, Somatostatin</DescriptorName><QualifierName MajorTopicYN="N">analysis</QualifierName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Sensitivity and Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Somatostatin</DescriptorName><QualifierName MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2000</Year><Month>8</Month><Day>10</Day><Hour>11</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>2</Month><Day>28</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2000</Year><Month>8</Month><Day>10</Day><Hour>11</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10930087</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour 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